The clinical, radiographic, and histopathological features have been described in detail. Gingival fibromatosis is a hyperplasia of the connective tissue of jaw periosteum, with no symptoms of inflammation or pain. Hgf is characterized as a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of keratinized gingiva. Hereditary gingival fibromatosis hgf is characterized by an accumulation of extracellular matrix resulting in a fibrotic enlargement of keratinized gingiva. This article revises the existing knowledge of different types of enlargements and highlights some important diagnostic. On intra oral examination there was presence of generalized firm swelling of the gingiva covering cervical and middle third of the clinical crown in anterior teeth and incisal surface in posterior teeth. Munagala karthik krishna, lumbini pathivada, gopinath. Gingival fibromatosis and significant tooth eruption delay in. Clinically, a pink gingiva with marked stippling can be seen to cover almost all the tooth, in many cases preventing. Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva summary by hart et al. Pathology, tokyo medical and dental university, 1545, yushima. The examined group consisted of 12 patients 8 males and 4 females aged 18 to 59.
Gingival fibromatosis, 1 genetic and rare diseases. A plantar fibroma is a noncancerous growth in the foot. Gingival fibromatosis with prunebelly syndrome mike harrison, bds, mscd, fdsrcspaed,a edward w. It can be inherited hereditary gingival fibromatosis hgf. Gingival fibromatosis figure 875 is familial or acquired due to treatment with phenytoin, cyclosporine, nifedipine, or other calcium channel blockers. Hereditary gingival fibromatosis describes a group of rare genetic conditions in which the gums become enlarged, growing over the teeth. Gingival fibromatosis represents the fibrous hyperplasia of the gingival tissue. Gingival hyperplasia is a bizarre condition causing esthetic. Some of the most commonly encountered exophytic gingival lesions are the irritation fibroma, peripheral ossifying fibroma, pyogenic granuloma, and peripheral giant cell granuloma. The oral manifestations of the condition are varied and depend on the severity and age of involvement. Gingival fibromatosis gf is a fibrous overgrowth of gingiva that maybe idiopathic or may have an inheritance pattern wherein it is known as hereditary gingival fibromatosis hgf.
Unilateral gingival fibromatosis abstract increase in size of gingiva is termed as gingival enlargement or gingival overgrowth. The histopathology features of hgf reveals dense connective tissue rich in collagen fibers and a hyperplasic epithelium with long rete pegs 8. Hereditary gingival fibromatosis hgf or idiopathic gingival fibromatosis is a rare, benign, asymptomatic, nonhemorrhagic and nonexudative proliferative fibrous lesion of gingival tissue occurring equally among men and women, in both arches with varying intensity in. Cephalometric findings showed severe mandibular deficiency and vertical. Hereditary gingival fibromatosis hgf is a rare condition which manifests itself by an enlarged gingival tissue covering teeth to various extents. Hereditary gingival fibromatosis hgf is a rare disorder characterized by a benign, nonhemorrhagic, fibrous gingival overgrowth that can appear in isolation or as part of a syndrome. A case of a 19yearold male presenting with maxillary and mandibular chronic inflammatory gingival enlargement associated with prolonged orthodontic therapy is reported here. Palmarplantar fibromatosis in children and preadolescents. Idiopathic gingival fibromatosis is a rare condition. Gingival fibromatosis is a rare condition in which accumulation of extracellular matrix components causes slowly progressive enlargement of the gingiva. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Histology of palmar fibromatosis and plantar fibromatosis. Hereditary gingival fibromatosis specifically occurs in the absence of other identifiable medical syndromes or medications known to cause gum overgrowth. A case is described of gingival fibromatosis in a 10.
The advantages of this method over conventional surgery were minimal bleeding and pain, allowing treatment of all quadrants in one visit. Gingival fibromatosis is a rare and heterogeneous group of disorders that develop as slowly progressive, local or diffuse enlargements within marginal and attached gingiva or interdental papilla. Gingival diseases in children free download as powerpoint presentation. This paper presents a case of 9yearold female patient suffering from hgf with chief complaint of mouth protrusion. This case report describes a 16year old female patient who presented generalized extensive gingival overgrowth, involving the maxillary and mandibular arches. Composed of broad, sweeping fascicles of monotonous spindle cells. Kavvadia k1, pepelassi e, alexandridis c, arkadopoulou a, polyzois g, tossios k. Hereditary gingival fibromatosis hgf is a rare condition which. In severe cases, the excess tissue may cover the crowns of the teeth, thus causing functional, esthetic, and periodontal problems, such as bone loss and bleeding, due to the presence of. Gingival fibromatosis 4 leukemic infiltrate gingivitis, local factors orthodontic brackets gingivitis, pregnancy hereditary gingival fibromatosis.
Hereditary gingival fibromatosis hgf is a rare condition presenting varied. Gingival hyperplasia is an overgrowth of gum tissue around the teeth. Pathology of juvenile hyaline fibromatosis dr sampurna. The gingival enlargement is particularly pronounced in the anterior maxillary region, but any region may become affected. It has a range of potential causes including genetics and chronic liver disease. Aug 22, 2011 gingival fibromatosis and hypertrichosis gfh is a form of ectodermal dysplasia, one of a group of syndromes deriving from abnormalities of the ectodermal structures, which include the hair. The diagnosis of these lesions is essential for their successful management and of the patient as a whole. Gingival enlargement is associated with multiple factors including inflammation, medications, neoplasia, hormonal disturbances and rarely heredity.
The fibrous hyperplasia is found along the alveolar ridge. The differential diagnosis of gingival hyperplasia includes calcium channel blockers, cyclosporine, familial gingival fibromatosis, gingivitis, leukemia, phenytoin, scurvy, trench mouth, valproic acid. It grows in the plantar fascia, in the arch of the foot. Monarchs tools are designed to make it easier to compare the signs and symptoms phenotypes of different diseases. Pubmed is a searchable database of medical literature and lists journal articles that discuss gingival fibromatosis, 2. Pdf gingival enlargement is one of the frequent features of gingival diseases. Bland nuclear features, and finely collagenous stroma. Hereditary gingival fibromatosis can occur as an isolated. Hereditary gingival fibromatosis is a rare benign oral condition characterised. Gingiva fibromatosis an overview sciencedirect topics. By haplotype construction and analysis in a 5generation chinese family segregating autosomal dominant hereditary gingival fibromatosis, ye et al.
Hereditary, druginduced, and idiopathic gingival overgrowth have been reported. It is usually inherited as an autosomal dominant trait, but some cases are idiopathic and others are produced by drugs. Gingival fibromatosis and significant tooth eruption delay in an 11yearold male. Gingival fibromatosis with multiple unusual findings. Hereditary gingival fibromatosis hgf is a rare gingival. Gingival fibromatosis with hypertrichosis syndrome is an extremely rare genetic condition characterized by profound overgrowth of hair and gums, as well as other variable features. In familial gingival fibromatosis, large connective tissue masses develop and may cover the teeth. We present a case of idiopathic gingival fibromatosis with its multidisciplinary approach of management. The lesion is considered part of an ossifying fibroma, but that. Unusual clinical and histologic findings in a child with. Sep 05, 2018 druginduced gingival fibromatosis is a common benign condition of the gums. You may need to register to view the medical textbook, but registration is free. Chronic inflammatory gingival enlargement associated with.
The histopathology of inflammatory gingival enlargement. Odell, bds, fds, msc, phd, mrcpath,b meena agrawal, frcs,c ravi saravanamuttu, bds, fds,d and peter longhurst, bds, fdsrcs,e london, united kingdom guys dental hospital and umds guys hospital a case is described in which a child appeared for evaluation with marked gingival overgrowth, facial. Hereditary gingival fibromatosis hgf, also known as idiopathic gingival hyperplasia, is a rare condition of gingival overgrowth. Maybe it implies a new syndrome within the spectrum of those including gingival fibromatosis. Giant maxillary gingival fibromatosis ka stephenson1, gj klopper2, j opperman3, c favara2 1ear, nose and throat department, great ormond street hospital for children, london, uk 2ear, nose and throat department, frere hospital, east london, south africa 3department of histopathology, tygerberg hospital, university of stellenbosch, south africa abstract. Palmar fibromatosis and plantar fibromatosis pathology. Clinical examination reveals enlargement of buccal and palatal gingival tissue. Click on the link to view a sample search on this topic.
Presence of generalized aggressive periodontitis in a case of otherwise nonsyndromic gingival fibromatosis opens avenues for research into the existence of a predictable association between the 2 entities. Medscape reference provides information on this topic. Rare case report of idiopathic gingival fibromatosis in. This condition has been noted to be present from birth it has a congenital presentation. Gingival enlargement is defined as an overgrowth or increase in size of gingivae. Gingival fibromatosis, 2 genetic and rare diseases. Gingival enlargement, also synonymous with the terms gingival hyperplasia or hypertrophy, is defined as an abnormal overgrowth of gingival tissues. The moderate forms of gingival fibromatosis are associated with formation of pseudopockets between the teeth and the enlarged tissue, whereas the most extensive forms can result in submersion of the teeth. Hereditary gingival fibromatosis hgf is a rare condition that can occur as an isolated disease or as part of a syndrome or chromosomal abnormality. Gingival fibromatosis is characterized by a large increase in the gingival dimension which extends above the dental crowns, covering them partially or completely. Hereditary gingival fibromatosis hgf is a rare gingival lesion 1 in 7,50,000 that presents as localized or generalized fibrotic enlargement of the attached gingivae as well as the gingival. Generalized gingival enlargement can be caused by a variety of etiological factors. There are a number of causes for this condition, but its often a symptom of poor oral hygiene or a side effect of using. In severe cases, the excess tissue may cover the crowns of the teeth, thus causing functional, esthetic, and periodontal problems, such as bone loss and bleeding, due to the presence of pseudopockets.
Gingival fibromatosis is a rare and heterogeneous group of disorders that develop as. Idiopathic gingival fibromatosis gf, also known as gingivomatosis, is a rare condition in childhood, with an unknown aetiology. In palmoplantar fibromatosis, sections show a dense fibrocellular tissue with mature collagen and nodular collections of myofibrocytes in various stages of maturation. Peripheral ossifying fibroma, also known as ossifying fibrous epulis, is a gingival nodule which is composed of a cellular fibroblastic connective tissue stroma which is associated with the formation of randomly dispersed foci of mineralised products, which consists of bone, cementumlike tissue, or a dystrophic calcification. In 1941, coolidge in his classical paper stressed the importance of local irrita tion as the main etiologic factor in the development of gingival hypertrophy or hyperplasia. In clinical dentistry, patients frequently report with isolatedregional or generalized gingival enlargements, which could fall under varied presentations. Histopathology of benign gingival fibroblastic lesions. Highly variable natural course, with up to 25% undergoing spontaneous regression increasing tendency to follow with observation only ann surg oncol 20. Pdf gingival fibromatosis is a rare and heterogeneous group of disorders. Characteristics and novel putative pathogenic mechanisms show all authors. Gingival fibromatosis can be caused by number of factors including inflammation, leukemic infiltration, and use of medications such as phenytoin, cyclosporine or nifedipine, 14 and vigabatrin.
The monarch initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Gingival fibromatosis with hypertrichosis syndrome. Surgical therapy was carried out to provide a good. Can be used with palpable masses of the extremities, abdominal, chest wall, breast, etc. Gingival fibromatosis definition of gingival fibromatosis. It can cover teeth in various degrees, and can lead to aesthetic disfigurement. It may be either hereditary or idiopathic, with hereditary examples occurring as an isolated finding or as part of a syndrome e. Hereditary gingival fibromatosis hgf or idiopathic gingival fibromatosis is a rare, benign, asymptomatic, nonhemorrhagic and nonexudative proliferative fibrous lesion of gingival tissue occurring equally among men and women, in both arches with varying intensity in individuals within the same family 1. Hereditary gingival fibromatosis is most commonly inherited in an autosomal dominant manner, meaning that each child of an affected parent has a 50% chance of developing the condition.
Hyaline fibromatosis syndrome proposed as an umbrella term for juvenile hyaline fibromatosis and infantile systemic hyalinosis since the two syndromes have significant clinicopathologic overlap j am acad dermatol 2009. Mar 01, 2020 pubmed is a searchable database of medical literature and lists journal articles that discuss gingival fibromatosis, 1. Gingival fibromatosis, macaca mulatta springerlink. Ligneous gingivitis, also known as destructive membranous periodontal disease or erroneously amyloidaceous gingival hyperplasia, is another. Introduction prevalence and aetiology gingival fibromatosis is a rare disease with a prevalence of 1 in 175,000 individuals and an equal distribution between males and females, characterised by a generalised or localised thickening of the gingival. In severe cases functional, periodontal, esthetic and psychological problems may occur. The histopathological picture was suggestive of gingival fibromatosis figure 2. Palmar fibromatosis and plantar fibromatosis represent essentially the same process effecting hands and feet respectively. The goal of this article is to describe one kindred affected with hgf and discuss the diagnosis, treatment, recurrence risk and histopathology features of the proband with mixed dentition. A complete hemogram was conducted with all the parameters within normal range. Histopathology of benign gingival fibroblastic lesions with special reference to odontogenic fibroma and recurrence rates. The condition may occur isolated or as part of a syndrome.
The objective of this work is to present a rarely occurring type of gingival fibromatosis. Histopathological evaluation of five unusual gingival enlargement. Idiopathic gingival fibromatosis associated with generalized. However, families with autosomal recessive inheritance and apparent maternal inheritance have also been reported. In severe cases, the gingival enlargement may cover the crowns of. Hereditary gingival fibromatosis also referred to as idiopathic gingival hyperplasia, elephantiasis gingivae etc. This paper describe the case of a 5yearold male child with extensive gingival enlargement covering almost all the maxillary and mandibular teeth resulted in. Sep 26, 2018 hereditary gingival fibromatosis hgf is a common, slowlyprogressing, benign condition of the gums. Gingival fibromatosis with prunebelly syndrome sciencedirect. Gist differs from desmoidtype fibromatosis in that it is stained for cd34 and cd117 stains, not usually expressed in desmoidtype fibromatosis. Department of cytology and normal histology and pathologogy, facultad. Gingival diseases in children dentistry branches medicine. Juvenile hyaline fibromatosis was first described first described by mc murray in 1873 as molluscum fibrosum and later named juvenile. Histopathology microscopic examination of the specimens confirmed that the general.
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